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Tennessee → Missouri · Interstate 40 / Interstate 65
What does it actually cost to drive from Nashville, Tennessee, to St. Louis, Missouri? The hard numbers: 481 km (299 miles) of pavement primarily along Interstate 40 / Interstate 65, 4h 35m behind the wheel, and roughly $40.20 in fuel alone — that is 43.7 liters (11.5 gallons) of regular unleaded at a 0.92 USD/liter benchmark. Anyone leaving Nashville, the capital of Tennessee and the country music capital of the world, typically carries samples, signed proposals, or service equipment to deliver in St. Louis, the historic Gateway to the West and a major Mississippi River freight port, and aims to be home the same evening. It is worth confirming whether the haul fits inside your daily hours-of-service window or whether an overnight at a midpoint hotel makes more sense. Applying the IRS standard mileage rate (2025) mileage rate of $0.43/km ($0.69/mile), the gross outbound reimbursement settles at $206.83. Attach the visit purpose, client name, and plate number to the Clara receipt so the journal entry lands directly in the business-travel expense account.